Flexible electronics has emerged as a promising field for the development of electronic devices with applications in wearables, biomedical sensors, and edible electronics. Biomaterials play a crucial role in fabricating flexible substrates, and the utilization of polymer blends offers exciting possibilities for tuning mechanical and chemical properties. This paper highlights the potential of a novel polymer blend based on ethyl cellulose (EC) and hydroxypropyl cellulose (HPC) in the fabrication of substrates for flexible electronics. By blending the two cellulose ethers, it is possible to tune the mechanical and chemical properties of the final substrate, tailored to meet specific requirements. To exploit such innovative green substrates for photolithographic processes, their stability, and processability is extensively investigated. The feasibility of photolithographic processes on such biodegradable and edible substrates is …